The Marseille Medical Genetics Center aims to contribute to a better understanding of rare genetic pathologies, and to explore their phenotypic and cellular consequences.

The aim is to develop tools for accurate diagnosis, optimized patient management and disease prevention.

Through its 8 research teams, the MMG aims to propose innovative therapeutic strategies:

Focus on research teams working in the field of AI/Health

 

Technological advances and the associated accumulation of biomedical databases offer unprecedented opportunities to better understand biological systems in both healthy and pathological states.

The Systems Biomedicine team aims to exploit this large-scale data to gain a better understanding of genetic diseases. To achieve this goal, the team develops and applies numerical approaches for the analysis and integration of multimodal biological data.

Research areas:

  • Recent development of a transfer learning algorithm for multi-omics data integration via matrix factorization,
  • Exploration of graph representation learning strategies for drug repositioning,
  • Systems biology studies to better understand the cellular role of proteins involved in myopathies and aging diseases.

 

The Systems Biomedicine team hosts the research group of Paul Villoutreix, awardee of an INSERM Junior Professorship.

 

Systems biology, which considers biological systems as networks of interactions between biological faculties, proposes a new approach to linking genotypes (e.g. genes and proteins, the building blocks of systems) to phenotypes (emergent properties of systems), in particular pathological phenotypes. The group is active in the field of systems biology, through the development of mathematical and computational tools based on network theory and their application to biological problems, with the ultimate aim of unravelling the relationships between genotype and phenotype in human disease.

 

The Systems Biomedicine team is involved in a number of local, national and Internationally-renowned projects:

  • At Aix-Marseille University, within the Marmara, Laënnec and Centuri Institutes ,
  • At national level, the team participates in the PEPR "Santé Numérique" program, notably in the M4DI and ai4scmed projects,
  • Internationally, the team is involved in EJP-RD.

Address: MMG

Faculty of Medicine

27, Bd Jean Moulin

13385 - Marseille Cedex 05

Telephone: 04 91 32 49 47

Mail: valerie.gall@univ-amu.fr

Website

The laboratory in pictures